SYRE Short Interest (September 15, 2026 Update)
Short interest for SYRE was 12.1M as of September 15, 2026, +2.3% from the prior report.
This page tracks SYRE short interest over time, including historical values, changes between reports, and days to cover.
Spyre Therapeutics, Inc. Commo | SYRE | Nasdaq | Latest report: September 15, 2026
At the latest settlement date of September 15, 2026, Spyre Therapeutics, Inc. Commo (SYRE) showed reported short interest of 12,129,443 shares. That compared with 11,859,975 shares in the prior report, a change of 269.5K shares, or +2.3%. The latest reported days to cover was 11.58, based on average daily volume of 1.0M.
The historical data currently tracked for SYRE includes 65 reported entries from November 30, 2023 to September 15, 2026. Over that span, reported short interest has ranged from 206.5K to 14.1M shares.
Extreme edge-case readings may reflect unusually low reported average volume.
| Settlement Date | Short Interest | Prior Short Interest | Change Shares | Change % | Average Daily Volume | Days to Cover |
|---|---|---|---|---|---|---|
| September 15, 2026 | 12,129,443 | 11,859,975 | 269.5K | +2.3% | 1.0M | 11.58 |
| August 31, 2026 | 11,859,975 | 11,755,434 | 104.5K | +0.9% | 1.2M | 9.69 |
| August 14, 2026 | 11,755,434 | 12,143,879 | -388.4K | -3.2% | 736.8K | 15.95 |
| July 31, 2026 | 12,143,879 | 12,508,710 | -364.8K | -2.9% | 898.5K | 13.52 |
| July 15, 2026 | 12,508,710 | 13,640,183 | -1.1M | -8.3% | 1.4M | 9.03 |
| June 30, 2026 | 13,640,183 | 12,616,535 | 1.0M | +8.1% | 2.5M | 5.56 |
| June 15, 2026 | 12,616,535 | 12,627,576 | -11.0K | -0.1% | 1.2M | 10.83 |
| May 29, 2026 | 12,627,576 | 12,417,051 | 210.5K | +1.7% | 816.2K | 15.47 |
| May 15, 2026 | 12,417,051 | 12,221,682 | 195.4K | +1.6% | 1.2M | 10.44 |
| April 30, 2026 | 12,221,682 | 11,672,747 | 548.9K | +4.7% | 1.2M | 10.04 |
| April 15, 2026 | 11,672,747 | 10,435,737 | 1.2M | +11.8% | 1.6M | 7.35 |
| March 31, 2026 | 10,435,737 | 9,997,086 | 438.7K | +4.4% | 909.1K | 11.48 |
| March 13, 2026 | 9,997,086 | 9,985,198 | 11.9K | +0.1% | 714.8K | 13.99 |
| February 27, 2026 | 9,985,198 | 9,862,924 | 122.3K | +1.2% | 803.7K | 12.42 |
| February 13, 2026 | 9,862,924 | 9,980,496 | -117.6K | -1.2% | 663.2K | 14.87 |
| January 30, 2026 | 9,980,496 | 10,069,741 | -89.2K | -0.9% | 492.0K | 20.29 |
| January 15, 2026 | 10,069,741 | 11,636,998 | -1.6M | -13.5% | 724.8K | 13.89 |
| December 31, 2025 | 11,636,998 | 11,818,159 | -181.2K | -1.5% | 827.6K | 14.06 |
| December 15, 2025 | 11,818,159 | 11,157,711 | 660.4K | +5.9% | 852.2K | 13.87 |
| November 28, 2025 | 11,157,711 | 12,464,842 | -1.3M | -10.5% | 611.0K | 18.26 |
| November 14, 2025 | 12,464,842 | 12,407,305 | 57.5K | +0.5% | 618.5K | 20.15 |
| October 31, 2025 | 12,407,305 | 13,390,470 | -983.2K | -7.3% | 1.0M | 11.89 |
| October 15, 2025 | 13,390,470 | 14,459,688 | -1.1M | -7.4% | 1.5M | 9.19 |
| September 15, 2025 | 13,780,763 | 14,087,087 | -306.3K | -2.2% | 483.0K | 28.53 |
| August 29, 2025 | 14,087,087 | 13,187,699 | 899.4K | +6.8% | 480.0K | 29.35 |
| August 15, 2025 | 13,187,699 | 12,879,446 | 308.3K | +2.4% | 432.4K | 30.5 |
| July 31, 2025 | 12,879,446 | 13,602,876 | -723.4K | -5.3% | 551.7K | 23.35 |
| July 15, 2025 | 13,602,876 | 13,486,500 | 116.4K | +0.9% | 588.2K | 23.13 |
| June 30, 2025 | 13,486,500 | 12,592,074 | 894.4K | +7.1% | 795.6K | 16.95 |
| June 13, 2025 | 12,592,074 | 12,090,208 | 501.9K | +4.2% | 461.5K | 27.28 |
| May 30, 2025 | 12,090,208 | 12,296,733 | -206.5K | -1.7% | 364.0K | 33.21 |
| May 15, 2025 | 12,296,733 | 12,553,112 | -256.4K | -2.0% | 592.7K | 20.75 |
| April 30, 2025 | 12,553,112 | 11,749,883 | 803.2K | +6.8% | 587.1K | 21.38 |
| April 15, 2025 | 11,749,883 | 11,358,696 | 391.2K | +3.4% | 1.0M | 11.52 |
| March 31, 2025 | 11,358,696 | 10,767,640 | 591.1K | +5.5% | 645.1K | 17.61 |
| February 28, 2025 | 10,022,703 | 9,923,952 | 98.8K | +1.0% | 623.3K | 16.08 |
| February 14, 2025 | 9,923,952 | 10,235,934 | -312.0K | -3.0% | 581.6K | 17.06 |
| January 31, 2025 | 10,235,934 | 10,003,304 | 232.6K | +2.3% | 611.0K | 16.75 |
| January 15, 2025 | 10,003,304 | 9,940,874 | 62.4K | +0.6% | 554.1K | 18.05 |
| December 31, 2024 | 9,940,874 | 9,620,365 | 320.5K | +3.3% | 499.9K | 19.88 |
| December 13, 2024 | 9,620,365 | 8,859,758 | 760.6K | +8.6% | 488.9K | 19.68 |
| November 29, 2024 | 8,859,758 | 8,040,536 | 819.2K | +10.2% | 925.9K | 9.57 |
| November 15, 2024 | 8,040,536 | 8,250,593 | -210.1K | -2.5% | 542.1K | 14.83 |
| October 31, 2024 | 8,250,593 | 8,413,483 | -162.9K | -1.9% | 359.7K | 22.94 |
| October 15, 2024 | 8,413,483 | 8,644,070 | -230.6K | -2.7% | 381.6K | 22.05 |
| September 30, 2024 | 8,644,070 | 8,724,826 | -80.8K | -0.9% | 828.7K | 10.43 |
| September 13, 2024 | 8,724,826 | 8,462,948 | 261.9K | +3.1% | 412.2K | 21.16 |
| August 30, 2024 | 8,462,948 | 8,042,707 | 420.2K | +5.2% | 422.7K | 20.02 |
| August 15, 2024 | 8,042,707 | 7,811,572 | 231.1K | +3.0% | 387.0K | 20.78 |
| July 31, 2024 | 7,811,572 | 9,053,899 | -1.2M | -13.7% | 440.1K | 17.75 |
| July 15, 2024 | 9,053,899 | 7,790,902 | 1.3M | +16.2% | 610.8K | 14.82 |
| June 28, 2024 | 7,790,902 | 4,842,295 | 2.9M | +60.9% | 1.8M | 4.3 |
| June 14, 2024 | 4,842,295 | 4,575,641 | 266.7K | +5.8% | 455.3K | 10.63 |
| May 31, 2024 | 4,575,641 | 4,517,727 | 57.9K | +1.3% | 295.4K | 15.49 |
| May 15, 2024 | 4,517,727 | 4,381,088 | 136.6K | +3.1% | 311.0K | 14.53 |
| April 30, 2024 | 4,381,088 | 3,555,205 | 825.9K | +23.2% | 313.1K | 13.99 |
| April 15, 2024 | 3,555,205 | 3,012,956 | 542.2K | +18.0% | 322.8K | 11.01 |
| March 28, 2024 | 3,012,956 | 2,878,707 | 134.2K | +4.7% | 523.8K | 5.75 |
| March 15, 2024 | 2,878,707 | 2,150,882 | 727.8K | +33.8% | 852.5K | 3.38 |
| February 29, 2024 | 2,150,882 | 1,590,726 | 560.2K | +35.2% | 627.5K | 3.43 |
| February 15, 2024 | 1,590,726 | 710,964 | 879.8K | +123.7% | 343.1K | 4.64 |
| January 31, 2024 | 710,964 | 527,386 | 183.6K | +34.8% | 287.8K | 2.47 |
| December 29, 2023 | 372,854 | 215,128 | 157.7K | +73.3% | 102.6K | 3.63 |
| December 15, 2023 | 215,128 | 206,473 | 8.7K | +4.2% | 189.7K | 1.13 |
| November 30, 2023 | 206,473 | 139,688 | 66.8K | +47.8% | 93.1K | 2.22 |